{"id":16836,"date":"2017-09-22T11:39:08","date_gmt":"2017-09-22T09:39:08","guid":{"rendered":"https:\/\/news.save.ch\/?p=2265"},"modified":"2023-03-14T09:04:20","modified_gmt":"2023-03-14T08:04:20","slug":"plazentaschranke-medikation-fuers-ungeborene-kind","status":null,"type":"post","link":"https:\/\/news.save.ch\/fr\/plazentaschranke-medikation-fuers-ungeborene-kind\/","title":{"rendered":"Barri\u00e8re placentaire - M\u00e9dicaments pour l'enfant \u00e0 na\u00eetre"},"content":{"rendered":"
\"\"
Le mod\u00e8le cellulaire 3D d\u00e9velopp\u00e9 \u00e0 l'Empa permet d'\u00e9tudier la fonction de barri\u00e8re du placenta humain. Image : Empa<\/figcaption><\/figure>\n

Le f\u0153tus en d\u00e9veloppement est extr\u00eamement vuln\u00e9rable aux substances toxiques. M\u00eame les plus petites doses peuvent provoquer de graves dommages. L'une des t\u00e2ches du placenta est de prot\u00e9ger l'enfant \u00e0 na\u00eetre contre ces risques. Il s'agit d'une barri\u00e8re qui \"filtre\" les substances toxiques tout en fournissant au f\u0153tus les nutriments n\u00e9cessaires. Cependant, ces derni\u00e8res ann\u00e9es, de plus en plus de preuves montrent que la barri\u00e8re placentaire n'est pas 100% \u00e9tanche et que certaines Nanoparticules<\/a> peuvent franchir la barri\u00e8re.<\/p>\n

Les nanoparticules font leur entr\u00e9e dans un nombre croissant de domaines de la vie. Dans les cr\u00e8mes solaires, elles prot\u00e8gent contre Coup de soleil<\/a>Les nanoparticules permettent d'\u00e9viter que l'assaisonnement ne s'agglom\u00e8re, rendent les vestes imperm\u00e9ables et permettront \u00e0 l'avenir de transporter les m\u00e9dicaments au bon endroit dans le corps. \"Les femmes enceintes ne sont pour l'instant pas expos\u00e9es \u00e0 des quantit\u00e9s probl\u00e9matiques de nanoparticules, mais cela serait tout \u00e0 fait envisageable \u00e0 l'avenir en raison de la diffusion toujours plus large de ces minuscules particules\", estime Tina B\u00fcrki du d\u00e9partement \"Particles-Biology Interactions\".<\/p>\n

Pour assurer un d\u00e9veloppement s\u00fbr de Nanoparticules<\/a> dans les domaines d'application les plus divers, il convient d'\u00e9tudier plus pr\u00e9cis\u00e9ment les m\u00e9canismes d'absorption des nanoparticules au niveau de la barri\u00e8re placentaire ainsi que leurs effets sur la m\u00e8re, le placenta et le f\u0153tus. La taille, la charge, la composition chimique et la forme des nanoparticules pourraient par exemple avoir une influence sur leur capacit\u00e9 \u00e0 traverser la barri\u00e8re placentaire et sur les voies qu'elles empruntent. Cette recherche n'en est toutefois qu'\u00e0 ses d\u00e9buts. La fonction et la structure du placenta humain \u00e9tant uniques, les \u00e9tudes sur les mammif\u00e8res enceintes sont probl\u00e9matiques et peu concluantes. Les mod\u00e8les de barri\u00e8re placentaire humaine utilis\u00e9s jusqu'\u00e0 pr\u00e9sent sont soit tr\u00e8s longs, soit tr\u00e8s simplifi\u00e9s.<\/p>\n

Un mod\u00e8le 3D de la barri\u00e8re placentaire humaine<\/strong><\/p>\n

Pour de tels examens, on utilise volontiers un placenta donn\u00e9, pr\u00e9lev\u00e9 par c\u00e9sarienne apr\u00e8s la naissance de l'enfant. Il est reli\u00e9 le plus rapidement possible \u00e0 un syst\u00e8me de perfusion qui alimente le tissu en nutriments et en oxyg\u00e8ne. Ce mod\u00e8le tissulaire est certes le plus pr\u00e9cis, donc le plus pertinent sur le plan clinique, mais il est aussi tr\u00e8s exigeant sur le plan technique et limit\u00e9 dans le temps \u00e0 six \u00e0 huit heures de perfusion. En outre, il est certes possible de tester avec un placenta si une nanoparticule donn\u00e9e franchit la barri\u00e8re placentaire, mais il n'est gu\u00e8re possible d'\u00e9tudier la voie d'absorption des particules dans cet organe complexe.<\/p>\n

Texte : EMPA<\/a><\/p>\n

Retenir<\/span><\/p>\n

Retenir<\/span><\/p>\n

Retenir<\/span><\/p>","protected":false},"excerpt":{"rendered":"

Der sich entwickelnde F\u00f6tus ist \u00e4usserst anf\u00e4llig auf giftige Stoffe. Schon kleinste Dosen k\u00f6nnen gravierende Sch\u00e4den anrichten. Das ungeborene Kind davor zu sch\u00fctzen, ist eine der Aufgaben der Plazenta, eine Barriere, die Giftstoffe \u00abherausfiltert\u00bb, den F\u00f6tus gleichzeitig aber mit den notwendigen N\u00e4hrstoffen versorgt. Es gibt allerdings in den letzten Jahren immer mehr Belege daf\u00fcr, dass […]<\/p>\n","protected":false},"author":1,"featured_media":16225,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"pgc_sgb_lightbox_settings":"","footnotes":""},"categories":[3314],"tags":[2089,2182,2586,2591,2696,2697],"class_list":["post-16836","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-health-safety","tag-foetus","tag-giftstoffe","tag-naehrstoffe","tag-nanopartikel","tag-plazenta","tag-plazentaschranke"],"acf":[],"hkrextid":null,"publication":null,"issue":null,"workflow":null,"startPage":null,"spitzmarke":null,"_posts_by_tag_page_fields":{"widget_title":"","widget_tags":""},"_at_widget":"1","_yoast_wpseo_primary_category":"2","_yoast_wpseo_focuskw_text_input":"Plazentaschranke","_yoast_wpseo_opengraph-image":null,"_yoast_wpseo_opengraph-description":null,"_yoast_wpseo_opengraph-title":null,"enclosure":null,"_yoast_wpseo_twitter-title":null,"_yoast_wpseo_twitter-description":null,"_yoast_wpseo_twitter-image":null,"_wp_old_slug":null,"_yoast_wpseo_title":null,"_yoast_wpseo_canonical":null,"yoast_head":"\nPlazentaschranke \u2013 Medikation f\u00fcrs ungeborene Kind - Save<\/title>\n<meta name=\"description\" content=\"Mit dem 3D-Modell der Plazentaschranke lassen sich Erkenntnisse zu m\u00f6glichen toxischen Effekten auf das ungeborene Kind gewinnen.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/news.save.ch\/fr\/plazentaschranke-medikation-fuers-ungeborene-kind\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Plazentaschranke \u2013 Medikation f\u00fcrs ungeborene Kind - Save\" \/>\n<meta property=\"og:description\" content=\"Mit dem 3D-Modell der Plazentaschranke lassen sich Erkenntnisse zu m\u00f6glichen toxischen Effekten auf das ungeborene Kind gewinnen.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/news.save.ch\/fr\/plazentaschranke-medikation-fuers-ungeborene-kind\/\" \/>\n<meta property=\"og:site_name\" content=\"Save\" \/>\n<meta property=\"article:published_time\" content=\"2017-09-22T09:39:08+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-03-14T08:04:20+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/news.save.ch\/wp-content\/uploads\/2017\/09\/Plazenta-Stopperbild.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"870\" \/>\n\t<meta property=\"og:image:height\" content=\"490\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"\u00c9crit par\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/news.save.ch\\\/plazentaschranke-medikation-fuers-ungeborene-kind\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/news.save.ch\\\/plazentaschranke-medikation-fuers-ungeborene-kind\\\/\"},\"author\":{\"name\":\"admin\",\"@id\":\"https:\\\/\\\/news.save.ch\\\/de\\\/#\\\/schema\\\/person\\\/d49e199490bad7c70d64b9ab51142f2b\"},\"headline\":\"Plazentaschranke \u2013 Medikation f\u00fcrs ungeborene Kind\",\"datePublished\":\"2017-09-22T09:39:08+00:00\",\"dateModified\":\"2023-03-14T08:04:20+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/news.save.ch\\\/plazentaschranke-medikation-fuers-ungeborene-kind\\\/\"},\"wordCount\":395,\"commentCount\":1,\"publisher\":{\"@id\":\"https:\\\/\\\/news.save.ch\\\/de\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/news.save.ch\\\/plazentaschranke-medikation-fuers-ungeborene-kind\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/news.save.ch\\\/wp-content\\\/uploads\\\/2017\\\/09\\\/Plazenta-Stopperbild.jpg\",\"keywords\":[\"F\u00f6tus\",\"Giftstoffe\",\"N\u00e4hrstoffe\",\"Nanopartikel\",\"Plazenta\",\"Plazentaschranke\"],\"articleSection\":[\"HEALTH & SAFETY\"],\"inLanguage\":\"fr-FR\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/news.save.ch\\\/plazentaschranke-medikation-fuers-ungeborene-kind\\\/\",\"url\":\"https:\\\/\\\/news.save.ch\\\/plazentaschranke-medikation-fuers-ungeborene-kind\\\/\",\"name\":\"Plazentaschranke \u2013 Medikation f\u00fcrs ungeborene Kind - 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