{"id":3266,"date":"2018-10-02T16:00:02","date_gmt":"2018-10-02T14:00:02","guid":{"rendered":"https:\/\/news.save.ch\/?p=3266"},"modified":"2023-03-14T09:04:09","modified_gmt":"2023-03-14T08:04:09","slug":"neue-erkenntnisse-ueber-morbus-bechterew","status":null,"type":"post","link":"https:\/\/news.save.ch\/it\/neue-erkenntnisse-ueber-morbus-bechterew\/","title":{"rendered":"Nuove conoscenze sulla spondilite anchilosante"},"content":{"rendered":"
\"\"
La malattia di Bekhterev porta a un'infiammazione prolungata e dolorosa delle articolazioni e, infine, alla deformazione della colonna vertebrale. I ricercatori sospettano che una certa proteina sia la causa della malattia. \u00a9 Depositphotos\/lightsource<\/figcaption><\/figure>\n

La spondilite anchilosante porta a una prolungata e dolorosa Infiammazione delle articolazioni<\/a> e infine ad una deformazione del Dorsale<\/a>. I ricercatori sospettano che la causa della malattia sia una proteina specifica che la maggior parte dei pazienti ha nelle proprie cellule: la proteina HLA-B27. Le proteine si ripiegano in una struttura tridimensionale dopo essere state prodotte e i ricercatori sospettano che questa, la proteina HLA-B27, scateni la malattia a causa del suo ripiegamento particolarmente lento e complicato.<\/p>\n

Studio del trasporto della proteina HLA-B27<\/strong><\/p>\n

I ricercatori della Jacobs University, in collaborazione con i colleghi della Freie Universit\u00e4t di Berlino, hanno ora scoperto esattamente come avviene questo ripiegamento e il successivo controllo di qualit\u00e0 della proteina HLA-B27. La dott.ssa Zeynep Hein, postdoc nel gruppo di ricerca del Prof. Dr. Sebastian Springer presso la Jacobs University, ha studiato in dettaglio il trasporto della proteina HLA-B27 all'interno delle cellule umane.<\/p>\n

A questo scopo, viene prodotta una forma geneticamente stabilizzata della proteina HLA-B27 e confrontata con la proteina presente nel nostro corpo. \"Siamo sempre stati interessati al trasporto delle proteine nelle cellule e siamo abili nel creare proteine artificiali per studiare il processo di trasporto in questo modo\", spiega Hein. \"Questo progetto ha messo a frutto queste competenze e conoscenze\". Gli esperimenti sono condotti in coltura cellulare, quindi non con la partecipazione dei pazienti.<\/p>\n

Tra le altre cose, Hein e il suo team sono riusciti a scoprire che la proteina HLA-B27 pu\u00f2 ripiegarsi nella sua struttura speciale solo con grande difficolt\u00e0. E anche se riesce a ripiegarsi, la proteina tende a disintegrarsi immediatamente, perdendo cos\u00ec la sua funzione. \"Naturalmente, in questa fase non possiamo ancora dire in che modo queste scoperte fondamentali porteranno in seguito a un'eventuale Terapia<\/a> o curare la spondilite anchilosante\", afferma Springer. Ma lui e il suo team sono consapevoli da tempo di una cosa: \"La ricerca dei meccanismi fondamentali \u00e8 indispensabile per sviluppare terapie e farmaci.<\/p>\n

Fonte:<\/strong>
\nZeynep Hein, Britta Borchert, Esam Tolba Abualrous, Sebastian Springer: meccanismi distinti controllano l'integrit\u00e0 strutturale di HLA-B*27:05 a livello intracellulare e di superficie. PLOS ONE<\/em> (2018), doi:10.1371\/journal.pone.0200811<\/a>.<\/p>\n

Testo: Universit\u00e0 Jacobs di Brema <\/a><\/p>","protected":false},"excerpt":{"rendered":"

Morbus Bechterew f\u00fchrt zu langwierigen und schmerzhaften Entz\u00fcndungen der Gelenke und letztlich zu einer Verformung der Wirbels\u00e4ule. Forscher vermuten als Ursache f\u00fcr die Krankheit ein bestimmtes Protein, welches die meisten Patienten in ihren Zellen aufweisen: das HLA-B27-Protein. Proteine falten sich nach ihrer Herstellung in eine dreidimensionale Struktur, und Forscher vermuten, dass dieses das HLA-B27-Protein durch […]<\/p>\n","protected":false},"author":1,"featured_media":16302,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"pgc_sgb_lightbox_settings":"","footnotes":""},"categories":[1,3314],"tags":[1713,1981,149,2332,2559,2718,64,3254],"class_list":["post-3266","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-allgemein","category-health-safety","tag-auto-immunerkrankungen","tag-entzuendung","tag-gesundheitsschutz","tag-jacobs-university","tag-morbus-bechterew","tag-protein","tag-studie","tag-wirbelsaeule"],"acf":[],"hkrextid":null,"publication":null,"issue":null,"workflow":null,"startPage":null,"spitzmarke":null,"_posts_by_tag_page_fields":{"widget_title":"","widget_tags":""},"_at_widget":"1","_yoast_wpseo_primary_category":"4","_yoast_wpseo_focuskw_text_input":"Morbus Bechterew","_yoast_wpseo_opengraph-image":null,"_yoast_wpseo_opengraph-description":null,"_yoast_wpseo_opengraph-title":null,"enclosure":null,"_yoast_wpseo_twitter-title":null,"_yoast_wpseo_twitter-description":null,"_yoast_wpseo_twitter-image":null,"_wp_old_slug":null,"_yoast_wpseo_title":null,"_yoast_wpseo_canonical":null,"yoast_head":"\nNeue Erkenntnisse \u00fcber Morbus Bechterew - 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